Clinical Care Guidelines and Resources

The U.S. Department of Health and Human Services (HHS) issues a series of guidelines to help health care professions provide care and treatment to people with HIV in the U.S. HRSA has developed complementary clinical protocols and practices that provide information on the effective delivery of HIV care.

HHS Clinical Guidelines

Clinical guidelines outline the science and recommendations the care and treatment of people with HIV. These clinical guidelines include content related to antiretroviral therapy, opportunistic infection treatment, prophylaxis, COVID-19 (interim guidelines) and more. The guidelines also provide recommendations for conducting HIV testing and counseling.

These guidelines and recommendations are intended for health care professionals, public health professionals, Ryan White HIV/AIDS Program recipients, program managers in clinical and non-clinical settings, people with HIV, and the general public.

These clinical guidelines are frequently updated.

Reference Guides for Optimizing Care for People Aging with HIV

As people with HIV age, their health care and social needs change. All member of the health care team can assist in the care and treatment as people age with HIV. HRSA has two reference guides to assist health care professionals as their aging population grows. 

  • Incorporating New Elements of Care (PDF - 130 KB): This reference guide identifies commonly occurring health care and social needs of people aging with HIV and highlights the screenings and assessments for these needs. This reference guide serves as a starting point for health care teams as they build and expand their knowledge and practice of serving people aging with HIV.
  • Putting Together the Best Health Care Team (PDF - 138 KB): This reference guide discusses how all members of the health care team can contribute to the care of people aging with HIV. Specifically, this reference guide identifies roles, responsibilities, staff training, and resources for the health care team to build their capacity and may assist the health care team as they build and expand their knowledge and practice of serving people aging with HIV.

Clinical Protocols and Practices

The following HIV-related protocols and clinical practices have been developed by various panels of HRSA experts and other leaders in the field of HIV care and treatment.

Current Editions

Guide for HIV/AIDS Clinical Care, 2014 (PDF - 6 MB)

Archived Editions

A Guide to the Clinical Care of Women with HIV, 2013 (PDF - 4.7 MB)

A Guide for Evaluation and Treatment of Hepatitis C in Adults Coinfected with HIV, 2011 (PDF - 381 KB)

Date Last Reviewed:  September 2020